Title : Phytomelatonin and Epigenetic counteracting skin aging and regulation of keratinocyte homeostasis by modulating specific microRNAs
Phytomelatonin (PM) gained the greatest interest for its application in agriculture and its use to improve human health conditions. PM based supplement has been shown to possess antioxidant capabilities because it functions as a free radical scavenger. Reactive Oxygen Species (ROS), induced by both intrinsic (peroxide production) and extrinsic (UV-radiation) factors are biochemical mediators crucial in skin aging. Skin aging is also regulated by specific microRNAs (miRs). Herein we have shown the effect of PM free radical scavengers on the human keratinocyte cell line HaCat and on ROS formation induced by both extrinsic and intrinsic factors as well as their capability to positively modulate a member of the hsa-miR-29 family linked to aging. Our result highlights the regulatory role of PM for the keratinocytes homeostasiShort Description of what will be discussed during the presentation.
Dr. Fabio Olivieri graduated in Veterinary Medicine at the University of Naples, also earning a post-graduate academic specialization in Food Inspection. Subsequently he obtained a second level Master in Homeopathy, Homotoxicology and Integrated Medicine. Now he is about to complete the Second Level Master in Psycho-Neuro-Endocrine-Immunology. He deals with scientific research in the branch of dermocosmetics and nutritional supplements. He teaches Neuroendocrinoimmunology at the Second Level Master of the University of Parma in Pathologies of animal behavior. He published the first double-blind vs. placebo study on the clinical oral administration of low-dose cytokines in the negativity of the herpetic genome in the spontaneous infection of the domestic cat.