Title : Association between androgenetic alopecia and risk of cardiovascular events in young males: A systematic review and meta-analysis
Abstract:
Background: Androgenetic alopecia (AGA), often known as male-pattern baldness, is a common dermatological illness that mostly affects men and is defined by gradual hair thinning and loss. Multiple studies have investigated the potential relationship between AGA and cardiovascular events; however, the nature of this association is still debated. Furthermore, the link between AGA and CVDs appears to be stronger in young male population.
Objective: To systematically review the literature and conduct a meta-analysis to assess the relationship between AGA and Cardiovascular Risk Factors in Young Adult Males (<40 years at diagnosis).
Methods: We searched MEDLINE, Embase, & Google Scholar electronic databases for studies evaluating the effects of AGA Cardiovascular risk factors in adults. Studies were included if they met predefined inclusion criteria. Data extraction and quality assessment were performed independently by two reviewers. Random-effects meta-analysis was conducted to estimate pooled effect sizes.
Results: The meta-analysis of three included studies, demonstrated a promising association between early-onset androgenetic alopecia (AGA) and cardiovascular risk, marked by elevated systolic blood pressure (SBP). The analysis indicated a noteworthy mean difference in SBP (μ ?= 9.6339), 95% CI: 0.8464 to 18.4215), affirming the significance of AGA as a potential indicator of cardiovascular risk. Despite the inherent variability of the data (I² = 91.7963%) due to fewer number of studies included, the robustness of the findings is underscored by a comprehensive prediction interval. One study was identified as a potential outlier, but no studies were found to be excessively influential.
Conclusion: Current research suggests a potential link between early-onset androgenetic alopecia (AGA) and cardiovascular events, yet is limited by the confounding presence of metabolic syndrome. Given its rising prevalence, further large-scale studies are essential to ascertain the condition's role as an independent risk factor. Early detection and management of early-onset AGA could be crucial in mitigating future cardiovascular risks, emphasizing the need for regular screening and awareness of associated health implications.
Audience Take Away Notes:
- The audience can use the findings of this research to aid their understanding of the potential relationship between early-onset androgenetic alopecia (AGA) and cardiovascular risk factors in young adult males. This knowledge can aid in early detection and management of AGA, potentially leading to better cardiovascular outcomes in this demographic
- Healthcare professionals can utilize this information to improve patient care by incorporating screening for AGA as part of cardiovascular risk assessment in young male patients. Researchers can build upon these findings to conduct further studies, potentially leading to the development of targeted interventions and treatment strategies. Policymakers can consider these findings when designing public health initiatives aimed at reducing cardiovascular disease burden
- It is valuable for expanding research agendas and teaching materials in various disciplines
- While this research may not directly impact designers, it offers valuable insights into potential early markers for cardiovascular risk, which can indirectly benefit designers by promoting overall health awareness and potentially reducing the burden of cardiovascular disease in society
- While not directly related to design, the information gleaned from this research can indirectly contribute to improving healthcare design by promoting a more holistic approach to patient care
- Emphasizes the importance of early detection and management of AGA for mitigating future cardiovascular risks
- Provides a foundation for future research aimed at elucidating the underlying mechanisms linking AGA and cardiovascular health
