Title : Effect of hormonal imbalance on the severity of acne in adults: A meta-analysis
Abstract:
1. Introduction:
Acne vulgaris is a prevalent skin condition that affects individuals of all ages, including adults. While its pathogenesis involves various factors such as sebum production, follicular hyperkeratinization, and inflammation, hormonal influences are thought to significantly contribute to the severity of acne lesions in adults. This meta-analysis aims to examine and quantify the relationship between hormonal imbalance and the severity of acne in adult populations.
2. Objectives:
To conduct a systematic review of the literature on the association between hormonal imbalances and adult acne.
To perform a meta-analysis to determine the effect size of hormonal factors on the severity of adult acne.
To identify potential sources of heterogeneity and conduct subgroup analyses when applicable.
3. Research Questions:
Is there a statistically significant relationship between hormonal imbalance and the severity of acne in adults?
Do specific hormonal factors, such as androgens or estrogens, have a more pronounced effect on acne severity in adults?
4. Methods:
4.1 Literature Search:
A comprehensive literature search will be conducted using databases including PubMed, EMBASE, and Web of Science. Relevant keywords such as "hormonal imbalance," "adult acne," and "acne severity" will be used to identify potential studies.
4.2 Eligibility Criteria:
Studies will be included if they meet the following criteria:
• Focus on adult populations (18 years and older)
• Investigate the relationship between hormonal factors and acne severity
• Report quantitative data that can be used in a meta-analysis
4.3 Data Extraction:
Two independent reviewers will extract data from selected studies, including study design, sample size, hormonal factors examined, and relevant outcome measures.
4.4 Quality Assessment:
The quality of included studies will be assessed using appropriate tools such as the Newcastle-Ottawa Scale for observational studies and the Cochrane Risk of Bias tool for randomized controlled trials.
4.5 Data Analysis:
A random-effects meta-analysis will be conducted to estimate the effect size of hormonal imbalance on acne severity. Subgroup analyses will be performed to explore potential sources of heterogeneity.
5. Expected Results:
We anticipate finding a significant association between hormonal imbalance and the severity of acne in adults. Subgroup analyses may reveal which specific hormonal factors exert a more substantial influence.
6. Ethical Considerations:
This meta-analysis involves the synthesis of data from previously published studies; thus, ethical approval is not required.
7. Dissemination and Knowledge Translation:
The findings will be disseminated through publication in peer-reviewed journals, presentations at relevant conferences, and summaries for dermatologists and healthcare providers.
8. Conclusion:
This meta-analysis aims to provide a comprehensive assessment of the relationship between hormonal imbalance and the severity of acne in adults. By quantifying the impact of hormonal factors, this study contributes to a better understanding of adult acne pathogenesis.
