Title : Effect of skin elasticity improvement and anti-oxidant activity of stem cells extract derived from cambium of aloe vera
Abstract:
In this study, stem cells were extracted from the callus derived from the Aloe vera cambium, and the antioxidant activity and effect of skin elasticity improvement were assessed. The Aloe vera cambium-derived stem cell extract, AloStemTM and callus showed the survival rate of each 98.27% and 71.31%. In the results of the DPPH antioxidant activity of AloStemTM and Aloe vera extract, it was confirmed that the antioxidant effect of AloStemTM was more than twice that of Aloe vera extract. AloStem did not affect the cytotoxicity of normal human dermal fibroblasts (NHDF) cells up to 0.25% concentration. Also, AloStemTM increased elastin, COL1A1 and HAS2 mRNA expression levels dose-dependently. Furthermore, to examine lifting effect of skin elasticity using a sheet mask containing AloStemTM, 21 adult men and women applied the sheet mask in the face, once a day for 2 weeks. As a result, after 2 weeks the skin length was 116.75 ± 5.58 mm before the use of the sheet mask, but after 2 weeks of use, it was confirmed that 0.59% increased to 117.44 ± 5.17 mm. Thus, we concluded that the sheet mask containing AloStemTM can help the lifting effect of skin elasticity.
