Title : Detection of Ureaplasma urealyticum and Herpes virus infection in patients with Behcet’s disease
Behcet's disease or “silk road disease” got its description at the beginning of the last century. The etiological factors of Behcet’s disease (BB) are still under study. Some authors hold an opinion on the trigger role of the herpes simplex virus, and other infections in the development of this pathology. Ureaplasmas are a frequent associated microorganism in bacterial vaginosis, aggravating the degree of vaginal dysbacteriosis. An important feature of ureaplasmas is the ability to hydrolyze urea to ammonia, i.e. the presence of urease activity, and this in turn leads to damage of the epithelium and may contribute to the further prolonged development of BB. In this connection, ureaplasmas can contribute to the occurrence of erosive-ulcerative lesions of the mucous membrane.The aim of our investigation was to study the presence of the most common STIs from the “new generation” in patients with BB, and to evaluate the results of antimicrobial treatment. In patients with BB, was noted an increased frequency of detection of Ureaplasma urealyticum and herpes virus infections (50-75%). In the course of specific antibacterial / antiviral treatment, the following results were obtained: a decrease in the intensity of pain, disappearance of inflammation and discharge from the genital tract, an improvement in the psycho-emotional state of patients, the restoration of the skin process manifested in decrease of erosions, ulcers, and restoration of the skin of the genitals. The results obtained may indicate a direct or indirect role of Ureaplasma urealyticum and HSV type I and II in the pathogenesis of BB. In this connection, prior to treatment, patients with BB should be examined for the above infections. When prescribing a course of treatment, patients with BB should be guided by the recommendations for the treatment of Ureaplasma urealyticum and Herpes Virus infections.