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Khalidova Khalida Rashidovna, Speaker at
Ministry of Health of the Republic of Uzbekistan,
Title : Sexually transmitted infections in patients with genital dystrophic diseases


Genital dystrophic diseases represent  interdisciplinary problem, a successful solution that will significantly reduce the risk of malignant transformation. The literature describes a number of reasons, may cause dystrophic changes. The aim of the study was to determine  the spectrum sexually transmitted infections  in patients with genital dystrophic diseases and evaluate their possible role in the development of dystrophy. We observed 30 patients aged 6 to 64 years, among which there are lichen sclerosus, hyperplastic dystrophy, leukoplakia. All patients were carried PCR and microbiological research separated the urogenital tract. STI and the accompanying microflora as a mono-infection or in combination were detected in each patient. In the course of studies  exposed: in 26.7% of patients -Ureaplasma urealyticum, 10% - Chl. trachomatis, 43.3% - Gardnerella vaginalis, 3.3%- Mycoplasma genitalium, fungi of the genus Candida - 56.7%, CMV - 13.3%. HSV - 13.3%, HPV 16/18 at 46.7%. From the accompanying microflora St. epidermidis- in 20.0%, Enterobacter - 26.7%, St. aureus - 13.3%, St. Haemolyticus - 16.6%, St. saprophyticus - 16.6% Enterococcae spp. - at 6.7%.  We carried out a comprehensive therapy including antibiotics, anti-viral treatment, adjuvants and photodynamic therapy with photosens methylene blue from eight to ten sessions. As the result of the treatment, itching was stopped in 86.7% of patients. These results suggest that the key role in the origin of the itching  played pathogens such as  Ureaplasma urealyticum (26.7%), fungi of the genus Candida (56.7%), HPV 16/18 (46.7%), Enterobacter - at 26.7%. The origin of pruritus can be realized at the expense of the rich antigenic structure of these pathogens and the activation of kinin-prostaglandin system, which runs the enzymatic activity of some infections.


Dr. Khalidova Khalida Rashidovna has been working at the Republican Specialized Scientific and Practical Medical Center for Dermatovenereology and Cosmetology of the Ministry of Health of the Republic of Uzbekistan for 30 years. She is the head of the PCR laboratory, she has been studing and treating AIDS-associated diseases (Kaposi's sarcoma) and STD. She received PhD degree in 2000 at the same institution. She has published more than 200 research articles in different scientific journals.