Genital dystrophic diseases represent interdisciplinary problem, a successful solution that will significantly reduce the risk of malignant transformation. The literature describes a number of reasons, may cause dystrophic changes. The aim of the study was to determine the spectrum sexually transmitted infections in patients with genital dystrophic diseases and evaluate their possible role in the development of dystrophy. We observed 30 patients aged 6 to 64 years, among which there are lichen sclerosus, hyperplastic dystrophy, leukoplakia. All patients were carried PCR and microbiological research separated the urogenital tract. STI and the accompanying microflora as a mono-infection or in combination were detected in each patient. In the course of studies exposed: in 26.7% of patients -Ureaplasma urealyticum, 10% - Chl. trachomatis, 43.3% - Gardnerella vaginalis, 3.3%- Mycoplasma genitalium, fungi of the genus Candida - 56.7%, CMV - 13.3%. HSV - 13.3%, HPV 16/18 at 46.7%. From the accompanying microflora St. epidermidis- in 20.0%, Enterobacter - 26.7%, St. aureus - 13.3%, St. Haemolyticus - 16.6%, St. saprophyticus - 16.6% Enterococcae spp. - at 6.7%. We carried out a comprehensive therapy including antibiotics, anti-viral treatment, adjuvants and photodynamic therapy with photosens methylene blue from eight to ten sessions. As the result of the treatment, itching was stopped in 86.7% of patients. These results suggest that the key role in the origin of the itching played pathogens such as Ureaplasma urealyticum (26.7%), fungi of the genus Candida (56.7%), HPV 16/18 (46.7%), Enterobacter - at 26.7%. The origin of pruritus can be realized at the expense of the rich antigenic structure of these pathogens and the activation of kinin-prostaglandin system, which runs the enzymatic activity of some infections.