Homeostasis and regeneration of the skin are maintained by self-renewal, proliferation, and differentiation of tissue-specific stem cells. We have shown previously that the transcription factor p63 plays an essential intrinsic role in regulating self-renewal of skin stem cells. In this keynote speech, I will present three short stories developing in our laboratory surrounding the control of homeostasis and regeneration of the skin.
- Control of the cell cycle progression in skin stem cells by p63.
- Regulation of dermal adipocytes by skin stem cells via paracrine signaling.
- Rapid enrichment and expansion of skin stem cells for regenerative medicine.