Title : Combination therapy of JAK inhibitors and excimer lasers for alopecia areata.
Abstract:
Case 1: A 45-year-old woman. She developed alopecia areata at the age of 4 and treated with DPCP therapy, excimer light and oral steroid. Excimer laser irradiation was started, and hair growth was observed. But her alopecia is incurable because it is an ophiasis type. In the second year starting excimer laser irradiation, baricitinib 4 mg / day oral use was started. After 3 months, hair growth was also observed in the temporal and occipital regions. Case 2: A 12-year-old man. His has alopecia capitis totalis and treated by excimer light and SADBE therapy, but there was no improvement, and his eyebrows also fell out. Excimer laser irradiation started on the right half of the head, but hair growth was not observed. After 10 excimer laser irradiation, upadacitinib 15 mg/day oral use was started and significant hair growth was observed in the excimer laser irradiated area after 3 months. After that irradiation was also started on the left half of the head and eyebrows, and good hair growth was observed in all heads. Treatment of alopecia with JAK inhibitors has been reported, but alopecia requires longer administration than atopic dermatitis, and it should be considered that combination with excimer laser from the viewpoint of safety.
Audience Take Away Notes:
- Even if it is a facility to do ultraviolet treatment, the audience can do this combination treatment.
- By proposing treatment to patients with intractable alopecia, it is possible to relieve the worries caused by alopecia for patients and their families.
- Both excimer lasers and JAK inhibitors are effective for alopecia, but especially for intractable alopecia, the combination of excimer lasers and JAK inhibitors can be expected to improve treatment efficiency.
