Gene therapy for hairloss

Title : Gene therapy for hairloss

Abstract:

Recent advances in Epigenetics & Anti ageing medicine has discovered “molecules of interest” that influence our cells, including our stem cells at a genetic level. Use of this knowledge will help us provide better & holistic treatment for hairloss.
Molecules of interest
- Resveratrol
- NMN (Nicotinamide Mononucleotide)
- Fisetin
- Grapeseed extract
- Ca AKG or AKG
- Rapamycin
- Apigenin, and more…NMN & Grapeseed extract induce increased proliferation/multiplication in the stem cells of thinning/miniaturizing hair follicles (and in the hair in forced telogen phase in TE). Resveratrol & Fisetin increase TERT levels in the skin & increase rapidly multiplying Ki67+ cells around the hair follicle. These stimulate the stem cells in the hair bulge area to start multiplying. Fisetin, a senolytic, destroys the senescent cells. They also protect the niche of stem cells in the bulge area of hair follicle, thus, effectively reversing the hairloss process. Instead of looking for stem cell transplants or similar heroic measures, we should improve the epigenome and gene expression in the existing stem cells to delay their senescence (and thus, baldness). Research in genetics and antiageing medicine shows that we can change gene expression as well as influence the stem cell growth of hair follicles. This knowledge can be included in clinical practice to offer better hair regrowth treatment protocols especially in people suffering hairloss/AGA at young age.

Biography:

Dr. Arvind Poswal, an inventor, an artist, a perfectionist, a compassionate dermatologist and a teacher, is popular among his patients and peers alike. He completed his medical studies from the prestigious Armed Forces Medical College, Pune (India). He did Professional Diploma in Dermatology from Australia. His areas of special interest include Body hair to scalp transplant, dermatologic-aesthetic surgeries and anti-ageing/longevity medicine and Peptide- Gene therapies. For this, he also completed the Post Graduate program in Diabetology from Johns Hopkins University, Baltimore and Masters in Business Administration. He has been felicitated by heads of states and celebrities alike. Dr. Capt Arvind Poswal widely acclaimed for his contributions to the field of hair transplant. He is the inventor of the stitchless FUSE/fue technique and Beard hair to scalp transplant.Dr. Arvind Poswal : MBBS (AFMC), Prof. Diploma Dermatology, MHA, PGPD (Johns Hopkins), Dip.Pys, PCTD, PCP, Founder Member, FUE Europe, President, SHTS. He is also a member of the American Hair Loss Association, IAHRS, IPHA, SHTS, ESHRS, ISHRS, AHRS, FUE Europe, IFSCC.