Recent advances in Epigenetics & Anti ageing medicine has discovered “molecules of interest” that influence our cells, including our stem cells at a genetic level.
Use of this knowledge will help us provide better & holistic treatment for hairloss.
Molecules of interest
- NMN (Nicotinamide Mononucleotide)
- Grapeseed extract
- Ca AKG or AKG
- Apigenin, and more…
NMN & Grapeseed extract induce increased proliferation/multiplication in the stem cells of thinning/miniaturizing hair follicles (and in the hair in forced telogen phase in TE).
Resveratrol & Fisetin increase TERT levels in the skin & increase rapidly multiplying Ki67+ cells around the hair follicle. These stimulate the stem cells in the hair bulge area to start multiplying. Fisetin, a senolytic, destroys the senescent cells. They also protect the niche of stem cells in the bulge area of hair follicle, thus, effectively reversing the hairloss process.
Instead of looking for stem cell transplants or similar heroic measures, we should improve the epigenome and gene expression in the existing stem cells to delay their senescence (and thus, baldness). Research in genetics and antiageing medicine shows that we can change gene expression as well as influence the stem cell growth of hair follicles. This knowledge can be included in clinical practice to offer better hair regrowth treatment protocols especially in people suffering hairloss/AGA at young age.