Title : Gut feelings: Unveiling the skin's microbial metropolis via bile acid boulevard
Abstract:
Recent studies have unveiled a novel aspect of gut microbiota dynamics influencing skin health and dermatology: the gut-skin axis mediated by microbial metabolites, particularly bile acids. These bioactive molecules, primarily metabolized by gut bacteria, exert systemic effects on host physiology, including modulation of immune responses and inflammatory pathways. Furthermore, bile acids have been found to impact skin barrier integrity and lipid composition, implicating their role in dermatological conditions such as atopic dermatitis and psoriasis. Future research directions should explore the intricate mechanisms underlying bile acid-mediated gut-skin crosstalk, including the identification of specific microbial species and enzymatic pathways involved in bile acid metabolism. Moreover, exploring the therapeutic potential of targeting the gut microbiota-bile acid axis holds promise for innovative interventions in skin diseases, warranting further investigation into microbiota-targeted strategies and their clinical efficacy.
