Title : Gut harmony: Dancing short-chain fatty acids and skin health in the microbiome orchestra
Abstract:
Emerging evidence suggests a significant interplay between gut microbiota composition and skin health, particularly through the modulation of systemic inflammation and immune responses. Of particular interest is the role of short-chain fatty acids (SCFAs), microbial metabolites produced during fermentation of dietary fiber in the gut. SCFAs, such as butyrate, acetate, and propionate, have been shown to exert immunomodulatory effects by regulating the differentiation and function of immune cells, including T regulatory cells and dendritic cells, thus influencing cutaneous immune homeostasis. Additionally, SCFAs can regulate skin barrier function through their effects on keratinocyte differentiation and lipid production. Future research should focus on specific mechanisms by which gut-derived SCFAs impact skin health and disease, including their interactions with the skin microbiome and their potential as therapeutic targets in dermatological conditions characterized by dysregulated inflammation and barrier dysfunction. Moreover, exploring the influence of dietary interventions, prebiotics, and probiotics on gut microbiota composition and SCFA production holds promise for novel approaches in promoting skin health and managing dermatological disorders.
