Title : Personalized and precision medicine to secure the national biosafety: Towards individualized cosmetics, reconstructive plastic surgery and the modern beauty of the future to come?
Abstract:
Personalized Precision Medicine (PPM) as a New Model of Healthcare Services is the Unique Entity demonstrating an Integration of Fundamental & Clinical Science, Bioengineering & Translational ART, and IT Armamentarium, and Illustrating application of sets of the different tools at the Population, Community and Individuals, significantly optimizing the cost and efficacy of prophylactic, preventive and rehabilitative treatment for those who had fallen ill (patients) or for persons-at-risk. This strategy would give a real opportunity to secure preventive, prophylactic, therapeutic and rehabilitative measures whose personalization could have a significantly positive influence on demographics. PPM as being the Grand Challenge is rooted in a big and a new science generated by the achievements of: (i) systems biology & and (ii) biodesign-inspired translational medicine, whilst integrating platforms of OMICS-technologies, whose data is analysed, mined and clinically interpreted by a set of algorithms and software of bioinformatics, blockchain and artificial intelligence (AI). PPM is a goal of healthcare, in which diagnostic and treatment decisions are informed by each person's unique clinical, genomics-related, OMICS-supported portfolio, and IT tools. Meanwhile a combination of genomic and phenotypic biomarkers and thus translational tools of the next step generation are becoming of great significance to be translated into the daily practice. Individuals to be under regular monitoring that helps to detect pathological shifts at subclinical stages have a higher life expectancy and are able-bodied up to 8–15 years more than those under traditional treatment. This means that the society would save more than US$20,000–40,000 per person annually. At the communi-ty level, the annual savings from each individual may vary from several thousands to several tens of thou-sands U.S. dollars. The latter needs to develop a Personalized Health Plan addressing lifestyle, risk modifi-cation and disease management, and Personalized Health Management & Wellness Program, to support safe and effective deployment of the new enabling diagnostic and therapeutic technologies not to treat but to get cured and to keep yourself healthy, fresh, lovely attractive and young. You as The Grant Art-related Physicians (GARP) would need your adaptability more than ever to imple-ment PPM-related innovations into your brilliant art practices. Regarded as innovators and early adopters, cosmetologists and plastic surgeons stand at the forefront of novel medical advancements, incorporating new technologies into their practice with ease. And being cos-metologists, you must be prepared for the integration of patient and system factors. And thus teams of high-ly skilled plastic and reconstructive surgeons, cosmetologists and physicians of the next-step generations would tailor the care of each patient to meet their specific needs, whilst offering personalized treatment plans, guiding the patient through each step of the multistage process, providing the highest level of care to all of the patients and achieving natural and aesthetically beautiful results via natural and engineered bio-products.
For instance, skin nanobiosensors are already used in the cosmetics industry, or moisture sensors to meas-ure their skin hydration. The market for skin sensors technologies will reach $275 million by 2030! And in tandem with digitization comes the demand for personalization. Skin sensors would play a crucial role soon - both in helping the consumer quantify changes that are imperceptible to the naked eye, but also with the possibility of sending valuable big data back into profiled research and targeted development for the next generation of products. For instance, developed by the L’Oréal, the Perso smart skincare system is capable of providing individual-ized skincare solutions via a four-step process taking into account the specificities of the user’s skin, local weather conditions, and the user’s product preferences. According to L’Oréal, the device is also able to make custom formulas for lipstick and foundation. Amorepacific presented a 3D face mask printing system coupled with the 3D printing system developer Lincsolution. The latter uses a smartphone app to instantly measure individual users’ facial dimensions and print a personalized hydrogel mask that caters to individual facial features and skin conditions. P&G Ventures, the startup studio within Procter & Gamble, returned to CES 2020 to showcase the devel-opment of Opte Precision Skincare System. This personalized handheld inkjet printer can instantly make the appearance of skin’s hyperpigmentation disappear and fade spots over time. The integration of AI technology and the capture of Big Data techniques should foster the next great leaps in cosmetic medicine and plastic surgery as segments of the Art Medicine, allowing you to capture the de-tailed minutiae of PPM. For instance, Individualized & Optimal Wound Care relies on timely treatment de-cisions, which require an evaluation of multiple characteristics and patient-specific factors that can be made more efficient with the use of AI, which, in turn, can be used to predict the percentage of affected tissue and wound healing time, helping surgeons formulate treatment plans, avoid wound infections, and enhance patient care. AI-based imaging has also the potential to improve breast cancer prevention strategies by differentiating between risk levels of breast lesions while incorporating patient-specific information to deduce the optimal course of action. And final diagnostic accuracy can be greatly improved by AI-based image detection, which can reduce the error rate from 3-4% to 0.5%. In the future, precise monitoring of patient photographs may allow surgeons to monitor post-operative progress with real-time updates and save patients an in-person visit. Meanwhile, although such technologies are not yet available in plastic surgery, there is significant potential for AI-assisted plastic and reconstructive surgery in the near future to come.
Meanwhile, Opte’s digital camera scans the skin and instantly analyzes each image using a proprietary algo-rithm to detect tonal imperfections not visible to the human eye. The device then precisely deposits droplets of Spot Optimizing Serum on target areas until there is a perfect color match with the surrounding skin tone.
To utilize PPM resources and optimize the response to targeted therapies, molecular, clinical, genetic, and epigenetic factors will need to be taken into consideration in future research trials. With the emergence of novel preventive rehabilitative safety therapies from current clinical trials, dermatologists will be able to implement them into their daily practice and switch from a generalized “onedrug- fits-all” approach to more personalized “client-specific” management. T
The individualized molecular profiling and analysis could also tell you what kinds of foods to eat for younger, more radiant skin. Based on all of these measurements, you’ll get targeted product recommenda-tions (across brands) for your skin’s unique needs, down to different products for specific areas of your face, skin and body as a whole. In the wellness sphere, precision tests are also used to define slow or fast metabolizers. While genomic-based customized nutrition is already being implemented, PPM-based diets might lack sufficient evidence for full integration into the full-set cosmetic setting. Cosmetology require doctors to make treatment decisions based on patient self-reporting, which poses chal-lenges including patient recall or recognition of exacerbating factors, leading to a trial-and-error approach to management and additional consultations. Meanwhile, a lack of particular medical guidelines has been iden-tified by the majority of responders as the predominant barrier for adoption, indicating a need for the devel-opment of best practices and guidelines to support the implementation of PPM. Implementation of PPM re-quires a lot before the current model “physician-patient” could be gradually displaced by a new model “medical advisor-healthy person-at-risk”. This is the reason for developing global scientific, clinical, social, and educational projects in the area of PPM to elicit the content of the new branch. So, just keep you on the way to feel and to understand that the Grand Change and Challenge to secure our health and wellness are rooted not in Medicine, and not even in Science! Just imagine where?! In the up-graded Hi-Tech Culture! And only Creative Minds would be able to Re-Imagine Healthcare, to Transform Procedures and Prescriptions, and to Augment Physician Capabilities. This approach (PPM) mentioned should be based on postulates which will change the incarnate culture and social mentality!
Audience Take Away Notes:
- To learn more about the im-pact of PPM in the daily practice of cosmetologists, plastic surgeons and beaty experts
- To outline individualized strategy for the practice of cosmetologists to use PPM resources in their own practice
- For con-structing their training lecture of the next step generation in the area of beaty futureTo define a scope of the ways to overcome barriers stopping down the solvation of the cosmetology-related problems
