Title : New opportunities in the treatment of ulcerative skin lesions
Abstract:
In dermatological practice, treating ulcerative lesions of the skin is particularly relevant. In order to search for new therapeutic possibilities, the Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology has developed a new domestic drug "Glaucocide," which belongs to the latest generation of antiseptic agents, containing a modern antiseptic and a surfactant - activated glauconite. The drug was applied to the lesions by spraying 2-3 times a day for 10 to 30 days.
Purpose of the Study: to assess the anti-inflammatory and wound-healing effectiveness of the drug "Glaucocide" in patients with erosive-ulcerative skin lesions.
Research Material and Methods: 49 patients with ulcerative lesions of the skin aged 16 to 57 years who received inpatient treatment at the RSNPMUDVIK of the Ministry of Health of the Republic of Uzbekistan were under observation. Of these, 28 were men and 21 were women. By nosological form, 28 patients with trophic ulcers (TU) and 21 patients with chronic ulcerative pyoderma were identified. All patients underwent clinical, microbiological, and statistical studies. To assess the monitoring of clinical manifestations, the "Individual Map for Assessing the Effectiveness of Drug Use" was used, indicating demographic data, previous treatment methods, and their effectiveness/ineffectiveness; clinical manifestations were also recorded in the dynamics of the process depending on the duration of therapy. Indicators of the wound process (symptoms and complaints) in points using a visual-analog scale (VAS), proposed by Zilberberg N. V., Kohan M. M., Kasheeva Ya. V. (2024), where points were calculated from 0 to 10 points. ("0" - absence of the symptom, and "10" - its maximum severity).Statistical processing of data using descriptive statistics methods.
To assess the monitoring of clinical manifestations, the "Individual Map for Assessing the Effectiveness of Drug Use" was used, indicating demographic data, previous treatment methods, and their effectiveness/ineffectiveness; clinical manifestations were also recorded in the dynamics of the process depending on the duration of therapy. Indicators of the wound process (symptoms and complaints) in points using a visual-analog scale (VAS), proposed by Zilberberg N. V., Kohan M. M., Kasheeva Ya. V. (2024), where points were calculated from 0 to 10 points. ("0" - absence of the symptom, and "10" - its maximum severity).Statistical processing of data using descriptive statistics methods.
Research Results: Clinical studies of patients showed that the use of "glaucocide" powder contributed to the accelerated resolution of ulcerative foci, noticeable absorption of the skin-pathological process on the 2nd day of treatment, disappearance of pain, cessation of purulent discharge, pronounced granulation and epithelialization, which averaged 7.1+0.2 and 7.3+0.14 points, respectively. The regression of the ulcerative process was 2.3 times higher compared to the indicators of the control individuals and constituted 70.3% of the pre-treatment level.
Microbiological studies have shown the negation of the pathogenic flora of staphylococcus spp. In the foci of ulcerative lesions of the skin.
Conclusion: Glaucocide powder is convenient to use, has good tolerance, has no side effects, which can be recommended in the complex therapy of erosive-ulcerative skin lesions, contributing to increased therapeutic effectiveness.
