Title : Determination of antinuclear antibodies in patients with psoriasis
Introduction – ds-DNA-IgG and ss-DNA-IgG are antinuclear antibodies (ANA) designed to determine autoimmune antibodies of class G (IgG) to double-stranded (undenatured) DNA (ds-DNA) and single-stranded (denatured) DNA (ss-DNA) in human serum. The aim of the study was to determine the level of dsDNA-IgG and ssDNA-IgG antinuclear antibodies in patients with psoriasis.
Materials and methods - there were 68 patients with psoriasis, 25 of which (36,8%) were women and 43 patients (63,2%) were men. In the age aspect, patients were divided: under 14 years - 1 (1,47), from 15 to 25 - 11 (16,7%), from 26 to 40 - 26 (38,23%), from 41 to 60 - 23 (33,82%), over 61 years old – 7 people (10,29%).
Results - ANA were found in 26 patients (38,24%) with psoriasis. At the same time, dsDNA-IgG values were higher than normal values in 8 (11,76%) patients (group 1), ssDNA-IgG were elevated in 18 (26,47%) patients (group 2), in 2 (7,69% ) patients (group 3) were increased both indicators. Elevating of indicators of ds-DNA-IgG and ss-DNA-IgG, depending on age; occurred in 1 (3,85%) patient under 14 years, in 2 (7,69%) from 15 to 25, in 9 patients (34,61%) from 26 to 40, in 11 (42,30%) from 41 to 60, in 2 (7,69%) over 61 years old. It is known that metabolic syndrome (MS) is a complex of metabolic disorders, which in each patient, depending on the individual genetic predisposition, may be manifested by obesity, hypertension, coronary heart disease and type 2 diabetes mellitus.
Conclusion - Thus, the obtained data indicate a high frequency of ANA ds-DNA-IgG and ss-DNA-IgG in patients with psoriasis with varying degrees of positivity, depending on the activity, the extent of the process, the presence of complications, the severity of the metabolic syndrome and the presence of another accompanying pathology.