Involving using of human stem cells in Androgentic Alopecia that holds a great promise. There are numerous sources of autologous human stem cells being used for the treatment for AGA. A recent new discovery source of autologous human stem cells is harvested from human hair follicles. Hair follicles are known to contain a well-characterized niche for adult stem cells : Mesenchymal stem cells in the dermal sheath and the bulge, which contains epithelial and melanocytic stem cells. Stem cells in the hair bulge, a clearly demarcated structure within the lower permanent portion of hair follicles, can generate the interfollicular epidermis, hair follicle structures, and sebaceous glands.
A new method to isolate human adult stem cells by mechanical centrifugation of punch biopsy from human hair follicles without culture condition. Area of punch biopsy at the mastoid process along the hair line demarcation bilaterally. Human follicle stem cells (HFSCs) is used, to improve the hair density in patients affected by Androgenetic Alopecia AGA in stage 2–5 as determined by the Norwood-Hamilton classification scale and few cases of Alopecia Areata.
It has shown that the isolated cells are capable to improve the hair density in patients affected by androgenetic alopecia (AGA) and in some cases of Alopecia Areata