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María Rincon, Speaker at
Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain
Title : Nanostructured Lipid Carriers gel for dermal delivery of Pranoprofen

Abstract:

Pranoprofen (PF), 2-(5H-[1] benzopyrano- [2, 3-b]-pyridin-7-yl) propionic acid, is a nonsteroidal anti-inflammatory drug used in ophthalmology. Recently, some articles have reported the effect of this drug for the treatment of skin diseases. Nanostructured Lipid Carriers (NLC) are one of the colloidal systems that have been most widely studied over the past few decades with the aim of improving the penetration and delivery of drugs in the skin.

Propose: Development and evaluation of carbomer gel bearing pranoprofen loaded nanostructured lipid carries as a means of exploring novel formulations to improve the biopharmaceutical profile of this drug for skin disorders.

Methods and Results: The PF-NLC were optimized by a factorial design and characterized physiochemically, subsequently these systems were incorporated in a matrix of carbomer gels and studies such as release, ex vivo permeation using human skin, in vivo biomechanical properties and irritation test were carried out. Moreover, stability studies were determined using a Turbiscan Lab.

ThePF-NLC-gels exhibited physicochemical characteristics andmorphological propertiessuitable for dermal application. Also, the release profile showed a hyperbola Kinetic model. No signs of skin irritancy were detected. The measure of the Trans epidermal water loss (TEWL) and stratum corneum hydration (SCH) showed an occlusive and a moisturizing effect. For the stability, formulations were stable for a period of 6 months. Taking into account these results, the PF loaded in nanostructured systems could be a new alternative for the treatment of skin disorders.

Biography:

María Rincón has completed her University Degree in Pharmacy – University of Salamanca. Spain. 2002 – 2007, Master in “Management and Production in Pharmaceutic Industry” – University of Salamanca. Spain. 2007-2008., Doctorate programme in Neurosciences “Morphologic and functional organization of Nervous System” – University of Salamanca. Spain. 2007-2009.She has done her Doctorate programme in Development and control of drug delivery systems “Lipid nanostructured systems of pranoprofen for dermal application” – University of Barcelona. She is a specialist in Industrial Pharmacy through national public examination (FIR) – University of Barcelona. 2015 – 2017.

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