Homeostasis and regeneration of the skin are maintained by selfrenewal, proliferation, and differentiation of tissue-specific stem cells. We have shown previously that the transcription factor p63 plays an essential intrinsic role in regulating self-renewal of skin stem cells. In this keynote speech, I will present three short stories developing in our laboratory surrounding the control of homeostasis and regeneration of the skin.
(1) Control of the cell cycle progression in skin stem cells by p63.
(2) Regulation of dermal adipocytes by skin stem cells via paracrine signaling.
(3) Rapid enrichment and expansion of skin stem cells for regenerative medicine.