Title : Evaluation of cutaneous rejuvenation associated with the use of ortho-silicic acid stabilized by hydrolyzed marine collagen
During the aging process, a significant reduction in several trace elements is observed, and silicon is one of them. The reduction of silicon levels results in decreasing in collagen synthesis by fibroblasts and in the activation of dermal collagenase. The main source of silicon in humans is obtained through absorption by the gastrointestinal tract, either from silica found in cereals, which has low bioavailability, or in the form of ortho-silicic acid, the most commonly absorbed form, which is found in low concentrations in water and beer. Studies have demonstrated that the therapeutic supplementation of organic silicon strengthens nail and hair, increases collagen and elastin synthesis, promotes maintenance of vascular elasticity and increases calcium fixation in bone tissue. Thus, the supplementation of silicon in the form of ortho-silicic acid stabilized by hydrolyzed marine collagen, water-soluble, a highly bioavailable form of silicon, can be used for skin rejuvenation. Our group research evaluated the skin changes associated with the use of orthosilicic acid stabilized by hydrolyzed collagen. The patients were randomized to receive 600 mg of ortho-silicic acid stabilized by hydrolyzed collagen (group 1, n = 11) or placebo (group 2, n = 11) to be taken 15 minutes before breakfast for 90 days. A total of 22 patients caucasian male and female volunteers from 40 to 60 years old were included. For analysis of the results, clinical, photographic, and patients’ subjective evaluations were conducted. Results of Clinical evaluations demonstrated changes in skin texture, firmness, and hydration statistically superior in group 1. Brightness, firmness, and overall appearance showed trends for a difference favoring group 1 according to patients’ subjective evaluations. Objective images showed no statistical differences. No side effects, hypersensitivity, or systemic symptoms were observed in group 1. Treatment satisfaction in group 1 reached 80%. The study showed that ortho-silicic acid stabilized by hydrolyzed collagen in a daily dose of 600 mg showed positive results in skin rejuvenation according to clinical evaluation in firmness, hydration, and skin texture. Further studies with larger and representative samples should be conducted to confirm our results.