The ability of tumour cells to adapt to environmental stress, including therapeutic insult, contributes to tumour evolution and drug resistance. Drug-tolerant persister (DTP) cells from multiple cancer types often exhibit elevated activation of the integrated stress response (ISR [....] » Read More
Acne vulgaris is a prevalent dermatological disease characterized by skin eruptions, which may decrease the sufferer’s quality of life. Hydrogen purification treatment is a new procedure used in cosmetology to improve the skin parameters of the face. This study examined the [....] » Read More
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Diagnosis of alopecia areata (AA) can be challenging when clinical presentation is not classical. One of the earliest and most important histopathological feature which we expect to see is the peribulbar lymphocytic infiltrate however it may not be appreciable in many cases [....] » Read More
Statement of the Problem: Increased affluence of society has meant more people today desires to look good, with unblemished, almost perfect skin. This is a challenge for practicing cosmetic dermatologists when treating hyperpigmentation especially with products that has low side [....] » Read More
Skin is the largest organ of the mammalian body, with significant functions in several biological processes, namely environmental barrier, tissue regeneration, hair cycling and wound repair. Skin is affected by several diseases, including cancer. Skin tumors are mainly of thre [....] » Read More
During the aging process, a significant reduction in several trace elements is observed, and silicon is one of them. The reduction of silicon levels results in decreasing in collagen synthesis by fibroblasts and in the activation of dermal collagenase. The main source of silicon [....] » Read More
Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and the hair (silver hair) with the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes.Three variants of disease have [....] » Read More
Ever since the days of Hippocrates (466-377 B.C.) some diagnostic importance has been given to the nails. With evolution, nails have become an important appendage of the body. A pink and lustrous nail has always been equated with good health. The rectangular nail plate rests on t [....] » Read More
Introduction Silicone is a chemical element with semimetallic characteristic, which is derived from cross-linked polymer with methyl siloxane as the basic element. In daily life, silicone can be found as simeticone (antifoams used in antacids), silicone oil for lubricant and c [....] » Read More
Low Level lasers… Effects Low-Level-Laser-Therapy of the BloodOne under laser blood irradiation, anti- inflammatory effects was observed that improved the immunologic activity of the blood 1.2. A fundamental finding was the positive influence on rheological properties o [....] » Read More
BACKGROUND Microneedling was initially introduced for skin rejuvenation, however, this minimally invasive procedure is now being used for the treatment of multiple dermatological conditions. Recent reports have shown its efficacy in the treatment of vitiligo. OBJECTIVE This re [....] » Read More
Botulinum toxin injections are the most popular performed aesthetic procedure. It involves the injection of precise units of the toxin targeting a specific muscle with ultimate aesthetic results. Despite being considered as a relatively safe procedure a series of adverse events a [....] » Read More
The idea of the treatment is to find an alternative natural way of treating Scars and acne instead of the usual Retinoid, fillers, other steroids and anti-biotics to get a long lasting result. We applied Multi-treapanic collage actuation method. This is a treatment that uses seve [....] » Read More
Fat Grafting An Ideal Filler For Contour Deformities With Hyperpigmentation On Face Background: Contour deformities of face are commonly associated with overlying skin hyperpigmentation. Such hyperpigmentation causes aesthetic problems as well as makes contour deformities more [....] » Read More
Background: To avoid catastrophic global repercussions of the novel coronavirus, several effective vaccines were introduced. With an increase in worldwide manufacturing and administration programs, there was also an increase in reports of vaccine’s side effects inc [....] » Read More
Background: Atopic dermatitis (AD) is associated with eczematous lesions, chronic pruritus, skin pain, sleep disturbance, all of which may negatively impact mental health and lead to depression. However, little is known about the predictors and longitudinal course of depressive s [....] » Read More
Objectives: To evaluate efficacy of addition of duloxetine to usual analgesic regimens in management of burn pain. Methods: In a 3-week open label randomized controlled trial, burn patients were assigned to the intervention (duloxetine 60mg/day+usual analgesic regimens) or contro [....] » Read More
Skin cancer is the most common cancer in the United States and among Caucasians worldwide, with more people diagnosed each year than all other cancers combined. Basal cell cancer is the most common form with an estimated 4.3 million cases diagnosed annually, and tr [....] » Read More
Background: Pemphigus Vulgaris (PV) is an autoimmune skin disorder characterized by painful blisters and erosions on the mucous membranes and skin which can be life-threatening if untreated. Typical treatments include systemic corticosteroids, topical steroids, tetracyclines, a [....] » Read More
Acne vulgaris is a prevalent dermatological disease characterized by skin eruptions, which may decrease the sufferer’s quality of life. The patients were divided into two groups. Group A underwent a sonophoresis procedure using ultrasound and ultrasound gel combined with a [....] » Read More
Background: Hair loss is a common condition, but there are significant limitations to present treatments. The promotion in the hair follicle cycle from the telogen to the anagen stage is the significant mechanism to regulate hair regrowth. Human amniotic epithelial cells (HAECs)- [....] » Read More
Melasma is a cosmetically disfiguring acquired hyperpigmented skin disorder. Many treatment modalities are being used and many are under trials for the treatment. No single treatment option has been associated with improvement and complete cure of the disease. Frequent rela [....] » Read More
Melasma manifests as hyperpigmented macules and patches, usually affecting the face, neck, and rarely upper limbs. This study evaluated comparative efficacy of a fractional CO2 laser with a Q-Switched Nd:YAG laser in combination therapy with tranexamic acid in refractory melasma. [....] » Read More
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer in the United States, after basal cell carcinoma. Ultraviolet radiation through sun exposure is considered the greatest risk factor, which explains why cSCC most typically presents on the face, neck, s [....] » Read More
Aging hands show soft tissue atrophy with prominent bones, tendons and visible veins as well as pigmentary changes & skin rhytids. Autologus fat grafting combined with PRP (Platelet rich plasma) sessions could be used in hand rejuvenation for improveme [....] » Read More
Maculopapular cutaneous mastocytosis, is a rare condition associated with an increased mast cell infiltrate with multiple hyperpigmented macules, papules or nodules and often accompanied by mast cell-mediator release related symptoms including flushing, nausea, diarrhoea, sh [....] » Read More
Introduction Eczema is a group of papulosquamous diseases in skin and has various types. It is a common skin condition marked by itchy and inflamed patches of skin. The main symptom of eczema is itchy, dry, rough, flaky, inflamed, and irritated skin. It can flare up, subside, [....] » Read More
Increasing interest in the hazardous properties of zinc oxide nanoparticles (ZnO NPs), commonly used as ultraviolet filters in sunscreen, has driven efforts to study the percutaneous application of ZnO NPs to diseased skin; however, in-depth studies of toxic effects on melanocyte [....] » Read More
Abstract: Genital warts (GW) are one of the most clinically pronounced manifestations of human papillomavirus infection (HPV), and many authors have already referred to the group of background diseases of the genitals. Given the growing prevalence of GW both among men and women a [....] » Read More
Abstract Importance: Keloid excision alone can have recurrence rates approaching 80%. Objective: To evaluate the clinical use of topical Imiquimod in prophylaxis of keloid regrowth post keloid excision. Design, Setting, and Participants: Our study is a retrospective case [....] » Read More
Title : An educational-artistic exhibition on the skin and the main dermatoses
Dechelette Corinne, PEAUrigami, France
No other organ in the human body has as many functions as the skin: biological, cultural, social and psychological. The skin is a sensory organ, of touch and expression. The skin is the first thing we notice and the basis on which we draw conclusions about a person. It provide [....] » Read More
Title : Stem cells in regeneration and cancer of epithelia
Makoto Senoo, Boston University School of Dental Medicine, United States
The skin is maintained by self-renewal, proliferation, and differentiation of tissue-specific stem cells. We have shown previously that the transcription factor p63 plays an essential role in these processes. Although p63 has high sequence and structural similarities to the tumor [....] » Read More
Title : Treating vitiligo with intense pulsed light (IPL)
Lee Kar Wai Alvin, EverKeen Medical Centre, Hong Kong
Background: Vitiligo is a long-term skin condition characterized by patches of the skin losing their pigment. This study evaluates the efficacy of Intense Pulsed light (IPL) for Chinese patients with vitiligo. Most of them are resistant to conventional vitiligo. We are presenting [....] » Read More
Title : Melanoma biology from the perspective of skin signaling and UV pathogenesis
DAVID E FISHER, Massachusetts General Hospital, United States
Cutaneous melanoma has undergone a revolution in therapeutic success during the past decade, due to major advances in both targeted therapy and immune therapies. Major insights have been gained through increased understanding of the pathways giving rise to melanoma through, [....] » Read More
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Title : Treating acne vulgaris patients who are resistant to oral isotretinoin, tetracycline, doxycycline with intense pulsed light (IPL)
Dr Lisa Chan, EverKeen Medical Centre, Hong Kong
Background Acne Vulgaris is a long-term skin disease that occurs when hair follicles are clogged with oil and dead skin cells from the skin. Severe cases were treated with oral doxycycline, tetracycline and even isotretinoin. Nevertheless, many cases were resistant to oral [....] » Read More
Title : Treatment of dry skin with an emulsion containing plant-based anionic phospholipids
Terrance L Baker, Johns Hopkins Medicine, United States
This study compares a skin cream emulsion containing a plant-based anionic polar phospholipid (APP) technology with a mineral oil hydrocarbon (petrolatum)-based (MHB) skin cream technology in the treatment of skin xerosis (dryness) in diabetic feet. Skin cream with APP technology [....] » Read More
Title : Efficacy of non-proteinogenic amino acid on dermal and basement membrane components
Jolanta Idkowiak Baldys, Avon Products Inc. Global Innovation Center, United States
Non-natural, non-proteinogenic amino acids are rather novel in the cosmetic industry. They do not become incorporated into proteins during new protein biosynthesis, and thus, topical application of these actives can lead to skin benefits. We previously demonstrated that a novel p [....] » Read More
Title : Role of aberrantly spliced stem cell factor p63 in the development of epithelial cancer
Keshia Pitt , Boston University School of Medicine, United States
p63, a homologue of the transcription factor p53, is essential for maintaining the proliferative capacity of epithelial stem cells. The p63 gene yields two major isoforms transcribed from dual promoters and at least three different splice variants at its carboxy-terminus. The TAp [....] » Read More
Title : Wound healing, tools in our arsenal
Amal Wagih, Cairo University, United Arab Emirates
Dermatologists face a wide array of ulcers and erosions in their practice, whether Decubitus ulcers, venous stasis ulcers, diabetic ulcers, traumatic wounds, burns, and leprosy trophic ulcers, or simply post burn ulcers and erosions, or disease induced ulcers as met in bullous di [....] » Read More
Title : Face liting – how to obtain the best results
Jose Eduardo Lintz, Instituto Ivo Pitanguy, Brazil
The author presents his experience in more than 2 thousands cases of facelifting and facial rejuvenation. Treating the skin and the muscles to achieve more natural and long results, dr lintz will show some of his results. Following the technique of the known reference [....] » Read More
Title : Meta-analyses about tranexamic acid in the treatment of melasma
Denise Steiner Reis Longhi, Mogi das Cruzes University, Brazil
This lecture will talk about the use of tranexamic acid for the treatment of melasma. Melasma is a prevalent and chronic disease which we don’t know the exact mechanism of action. There are a lot of stimuli to provoke it, for example: sun, hormones, stress, heat, local t [....] » Read More
Title : Neuroimmune basis of itch of scalp, clinics and approach to treatment
Svetlana Bobko, Moscow scientific and practical center of dermatovenereology and cosmetology, Russian Federation
Itch of scalp is a common problem in dermatovenereological practice. It can be a manifestation of inflammatory, infectious, autoimmune dermatoses, oncological pathology, neuropathic, systemic, psychogenic conditions and unknown etiology. It can be localized or generalized and not [....] » Read More
Title : Autologous fat grafting preserving adipose derived cells, new technologies and their impact on skin and hair care
Hebert Lamblet, Vikaara Klinik, Portugal
Besides the fact that fat grafting gained popularity, isolation of ADCs (Adipose Derived Cells) and fat tissue manipulation still remains controversial. In 2001, a putative Stem cell population was isolated within the adipose stromal compartment. Since then, many studies exhibite [....] » Read More
Title : Nanocarriers in cosmetics & skin care-a cosmetic chemist point of view
Federico Svarc, DQIAQF-INQUIMAE Buenos Aires University, Argentina
Many papers and reviews have been published during the last 10 years about transdermal bioactive nanocarriers. Nevertheless, most of those publications have been directed towards medical and therapeutic applications, where it is necessary to introduce drugs into the systemic circ [....] » Read More
Title : Skin cancer in Romania
Olga Simionescu, Olga Simionescu, Romania
”With a predominant third skin type population, Romania has recorded a huge progress in early detection of epidermal skin cancer, carcinoma and melanoma. Despite the fact that no melanoma centers exist and the patients require multiple visits in different depar [....] » Read More
Title : Dermal injection of hyaluronic acid in improving skin texture: from bench to bed
Yan Wu, Peking University First Hospital, China
Changes in skin quality include structural atrophy and functional defects of the epidermis and dermis caused by various reasons. These skin quality changes can manifest as dry skin and roughness, large pores, fine lines, acne scars and many more. Dermal injection of both non-cros [....] » Read More
Title : Towards developing personalized skin associated glucose biosensor diagnostics for type i diabetes
Nsrein Ali, University of Oulu, Finland
Coping with diabetes requires frequent invasive blood glucose-based monitoring. Partly for this reason, and also because of the associated reduced skin wound healing and consequent increased risk of infection, non-invasive glucose monitoring technologies are needed. We report her [....] » Read More
Title : Blaschkolinear dermatoses : a potpourri
Anupama Das, KPC Medical College and Hospital, India
Linear lesions are fairly common in our daily practice. However, the appearance of these lesions can vary, thus complicating the diagnosis. They act as diagnostic clues to many dermatological conditions, therefore, the importance of meticulous examination in clinical dermatology [....] » Read More
Title : Revolutionary natural biopolymers for wound healing therapy: borrowing from nature
Madhu Gupta, Delhi Pharmaceutical Science and Research University, India
Chronic, non-healing diabetic wounds put a massive economic burden on health services causing patient incompliance and discomfort. Thorough interpreting of chronic wound pathophysiology led to the fabrication of targeted systems of drug delivery that can improve and accelerate th [....] » Read More
Title : Green tea and its compounds in general skin care and acne vulgaris problems.
Vasiliki Roussou, University of Thessaly, Greece
It is well known that tea as a beverage, is one the most widely consumed ones. In fact, it is the second most consumed drink worldwide. Tea is available in plenty of forms and types, such as black tea, oolong tea and green tea. Furthermore, it is a nutritional treasure, as it con [....] » Read More
Title : The best efficacy treatment for alopecia androgenetic: A systematic Review and Meta-Analysis
Monica Trifitriana, Sriwijaya University, Indonesia
Androgenetic alopecia (AGA), is a genetically predetermined disorder due to an excessive response to dihydrotestosterone (DHT). Currently, non-surgical treatment of androgenetic alopecia is more in demand by patient. There are many non-surgical treatments, ranging from topical tr [....] » Read More
Title : Psoriasis let s think out of the box
Diaa Eddin M Jaber, Private Clinic, Jordan
Psoriasis is a chronic disease that causes the rapid buildup of skin cells. This buildup of cells causes scaling on the skin’s surface. Inflammation and redness around the scales is fairly common. Typical psoriatic scales are whitish-silver and develop i [....] » Read More
Title : The art in Follicular unit excision
Julieta Peralta Arambulo, Philippine Dermatological Society, Philippines
Follicular Unit Extraction or Follicular Unit Excision (FUE), is the latest technique and the major advancement in hair transplant surgery. FUE has evolved and improved substantially during this time and is believed to becoming even better because of recent innovations that in or [....] » Read More
Title : Treatment of dry skin with an emulsion containing plant-based anionic phospholipids
Jack V Greiner, Harvard Medical School, United States
This study compares a skin cream emulsion containing a plant-based anionic polar phospholipid (APP) technology with a mineral oil hydrocarbon (petrolatum)-based (MHB) skin cream technology in the treatment of skin xerosis (dryness) in diabetic feet. Skin cream with APP technology [....] » Read More
Title : Scalp rolling for alopecia areata: A case series
Bruin Pollard, Washington University School of Medicine, United States
Alopecia areata (AA) is a multifactorial autoimmune hair loss disorder with few treatments. We report five cases of AA refractory to conventional therapy who exhibited remarkable hair regrowth after adding scalp rolling as an adjuvant to topical clobetasol and minoxidil. These pa [....] » Read More
Title : 3-D analysis of fat graft survival in reconstructive breast surgery
Sophia Kivelitz, Technical University Munich, Germany
In Dermatological surgery and Plastic surgery Lipofilling is a common method to optimize surgical results in terms of reconstruction. Aside from its application on the entire body surface Lipofilling is particularly established in breast surgery. Since breast cancer is still t [....] » Read More