Neuroimmune basis of itch of scalp, clinics and approach to treatment

Itch of scalp is a common problem in dermatovenereological practice. It can be a manifestation of inflammatory, infectious, autoimmune dermatoses, oncological pathology, neuropathic, systemic, psychogenic conditions and unknown etiology. It can be localized or generalized and not always associated with skin conditions. Itch of the scalp is a manifestation of many dermatological diseases (seborrheic dermatitis, contact dermatitis, anxiety, lichen planopilaris, lice, psoriasis). Perifollicular inflammation, secretion of neurotransmitters (substance P), concomitant mental disorders can contribute to it.Red scalp syndrome, first described by Therstrup Pedersen in 1987, is accompanied by constant inflammation of scalp that is not caused by dermatologic disease of scalp and accompanied by itch and burning that can’t be treated by topical glucocorticosteriods or antiseborreic drugs, triggered by sun. The possible etiological and pathophysiological factors are perifollicular inflammation and increase of release of substance P close to affected hair follicles.There is connection with atopy or rosacea. Treatment includes sunscreen protection, soft shampoo, avoidance of contact irritation components.The purpose of this study is diagnostics and examination for differentiation of itch and red scalp syndrome.