Title : Unusual presentation of invasive cutaneous squamous cell carcinoma on posterior thigh
Abstract:
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer in the United States, after basal cell carcinoma. Ultraviolet radiation through sun exposure is considered the greatest risk factor, which explains why cSCC most typically presents on the face, neck, scalp, extensor forearms, dorsal hands, and shins 1 . Several other environmental exposures have also been associated with increased risk for cSCC including chemical agents, immunosuppressive medications, chronic inflammation of the skin such as with ulcers or sinus tracts, trauma, burns, and viruses, most notably HPV 2 . cSCC is often characterized as slow progressing, with metastasis of the lesion being rare (3-9%)3 . However, cSCC can emerge in “nontraditional” areas with aggressive characteristics, so clinical suspicion should remain high when examining open wounds and ulcers.