Title : Addressing the importance of animal models of skin cancer
Skin is the largest organ of the mammals’ body, with important functions in several biological processes, like environmental barrier, tissue regeneration, hair cycling and wound repair. Approximately 2 to 3 million non-melanoma skin cancers and 132,000 melanoma skin cancers are diagnosed annually worldwide. The skin tumors are mainly of three types: malignant melanoma, basal cell carcinoma and squamous cell carcinoma.Animal models are important tools to understand and follow several diseases, including skin cancer. In this way, in vivo studies are essential to improve and discover new strategies to prevent and better treat this type of cancer. This presentation intends to describe the rodent models available for skin cancer study, particularly the model skin cancer chemically-induced through the administration of the compounds 12-O- tetradecanoylphorbol-13-acetate (TPA) and Dimethylbenz[a]anthracene (DMBA).
What will audience learn from your presentation?
• Animal models of skin cancer
• Practical examples