HYBRID EVENT: You can participate in person at Tokyo, Japan or Virtually from your home or work.
Yuri Yogya, Speaker at Dermatology Conferences
INSDV, Indonesia
Title : Efficacy and safety of using non-insulated microneedle radiofrequency alone compared to in combination with polynucleotides for the treatment of periorbital wrinkles


Introduction: A few studies have evaluated the efficacy and safety of non-insulated radiofrequency microneedling (RFMN) to treat periorbital wrinkles in Asian patients. Recently, wound healing accelerators, the polynucleotides (PNs), have received  attention in wound management. However, their efficacy and safety have not been fullyelucidated following RFNM. This study aimed to evaluate the efficacy and safety of non10 insulated RFMN for periorbital wrinkles and the synergistic effect of PNs after RFMN.

Methods: Thirty subjects with Fitzpatrick skin types III to V and facial wrinkles (Fitzpatrick grades I and II) were enrolled. All volunteers were treated over the entire face with non-insulated RFMN for 3 sessions at 2-week intervals. The left and right sides of each patient’s face were randomly assigned to receive PNs (treatment group) or normal saline solution (control group). The indentation and maximum depth of wrinkles were objectively measured using Antera 3D. Subjective self-evaluations were obtained at baseline; 2 weeks after the third treatment; and at 1, 2, 3, and 6 months after the final treatment. In addition, pain scores, immediate reactions, and other adverse effects were evaluated.

Results: Twenty-nine subjects completed the treatment protocol. Most presented with grade II wrinkling (69%). At the 2-month follow-up, Antera 3D image analysis revealed a faster improvement for the treatment group. At the 6-month follow-up, the majority of the subjects reported an improvement of 25% to 75% in their periorbital wrinkles. The average pain score was 2.2 out of 10. No serious adverse events (infection, pigmentary alteration, persistent erythema, or scarring) were observed.

Conclusions: Non-insulated RFMN is safe and effective for treating periorbital wrinkles and can be used as a modality for transdermal drug delivery. Topical polynucleotides as an adjunctive treatment provide additional benefits for periorbital wrinkle treatment.

Keywords: Periorbital wrinkles; Polynucleotides; Radiofrequency; M 30 icroneedling; Transdermal drug delivery