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Reema Khalid Alessa, Speaker at Cosmetology Conferences
College of Medicine, Saudi Arabia
Title : Methotrexate associated reduced libido: A case report and review of the literature


Methotrexate (MTX) is an antimetabolite of folate that was originally developed as an antimalignancy drug. It was first introduced in the dermatology field by Gubner in 1951 after his incidental finding that psoriatic lesions improved after MTX treatment in a patient with cancer.1 Currently, MTX is used in a vast array of dermatological conditions. It has antiproliferative properties at a high dose and anti-inflammatory properties at a low dose through the inhibition of dihydrofolate reductase enzyme (DHFR). Reduced libido/impotence is considered a rare adverse effect (AE) of MTX. We report a case of a man with lymphomatoid papulosis (LP) who developed reduced libido after treatment with MTX. To our knowledge, only a few cases with loss of libido/impotence after MTX have been reported in the literatures. Dermatologists should be aware of this AE and discuss it with any patient for whom MTX is planned.


Dr. Reema Khalid AlEssa, a Doctor who graduated from College of Medicine, King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, MBBS degree with an excellent GPA and an Honour degree. She also has a second bachelor's degree in pharmacy from the College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia. She is one of the best Medical students with outstanding academic achievements. She won many awards at several national and international conferences, with Nine research publications in Dermatology.