Title : Embracing the potential of biopolymer based hydrogel: The new frontier in chronic wound therapy
Abstract:
Chronic, non-healing diabetic wounds put a massive economic burden on health services causing patient incompliance and discomfort. Thorough interpreting of chronic wound pathophysiology led to the fabrication of targeted systems of drug delivery that can improve and accelerate the wound healing process. Natural polymers or biopolymers are now explored for the fabrication of wound dressings. Polysaccharides elicit enormous and promising applications due to their extensive obtainability, innocuousness, and biodegradability. Various outstanding features of polysaccharides can be employed to fabricate biomimetic and multifunctional hydrogels as efficient wound dressings. These hydrogels mimic the natural extracellular matrix and also boost the proliferation of cells. Owing to distinctive architectures and abundance of functional groups, polysaccharide-derived hydrogels have exceptional physicochemical properties and unique therapeutic interventions. Hydrogels designed using polysaccharides can effectively safeguard wounds from bacterial attack. More research is required to engineer multifaceted advanced polysaccharide hydrogels with tuneable and adjustable properties to attain huge potential in wound healing. Chitosan- based hydrogels demonstrated better healing as they inhibited bacterial growth and expedited re-epithelization and cell proliferation. So, these hydrogels can be used for effective wound care offering truly valuable material in the field of wound healing and certainly opening new avenues for future research and development.
