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Vasiliki Lagouri, Speaker at Dermatology Conferences
University of West Attica, Athens, Greece
Title : Pomegranate's gift to skin: Unpacking the anti-aging and anti inflammatory power of polyphenols


The quest for radiant, healthy skin is a universal pursuit, and dermatologists constantly explore natural solutions to enhance their patients' well-being. Today, we delve into the promising world of pomegranate polyphenols, unlocking their potential benefits for diverse skin concerns. Pomegranate (Punica granatum L.) is one of the oldest edible fruits in the Meditterranean area and has been used extensively in the folk medicine. Popularity of pomegranate has increased tremendously especially in the last decade because of antimicrobial, antiviral, anticancer, potent antioxidant and antimutagenic effects of the fruit. Polyphenols, represent the predominant class of phytochemicals of pomegranate fruits, mainly consisting of hydrolysable tannins, gallotannins, ellagitannins and ellagic acid (EA). The present study was performed 1. to evaluate the pomegranate antoxidant/free-radical scavenging properties of the juice, peel and seed extracts of two cultivars from mainland Greece by using a) free radical scavenging (DPPH) and b) ferric reducing antioxidant power (FRAP) assays 2. to extract and measure the pomegranate polyphenols a) total phenols (TP), b) total flavonoids (TF), c) hydrolysable tannins (HT) and d) ellagic acid (EA) by using protocols of spectrometric and chromatographic methods.

Key Learnings:

  • Antioxidant Arsenal: Pomegranate boasts a wealth of polyphenols, nature's powerful antioxidants. These warriors combat free radicals, shielding skin from environmental assaults and premature aging. Dermatologists can leverage this knowledge to recommend pomegranate-rich products or even dietary guidance for patients seeking protection against sun damage, wrinkles, and hyperpigmentation.
  • Hydration Hero: Polyphenols' anti-inflammatory properties can alleviate skin irritation and dryness. This translates to calmer, plumper skin for patients with conditions like eczema or dermatitis. Dermatologists can incorporate pomegranate extracts into treatment plans or suggest topical options to soothe inflammation and promote optimal hydration.
  • Collagen Champion: Studies suggest pomegranate polyphenols stimulate collagen production, the skin's structural scaffolding. This translates to improved skin elasticity and firmness, a boon for patients combating fine lines and sagging. Dermatologists can advise on incorporating pomegranate-based products or supplements to support collagen synthesis and achieve a more youthful appearance.
  • Microbiome Maestro: Emerging research hints at the potential of pomegranate extracts to positively modulate the skin microbiome, the ecosystem of friendly bacteria crucial for healthy skin. This opens doors for exploring how such modulation can benefit various skin conditions. Dermatologists can stay informed about these developments and potentially integrate them into future treatment approaches.
  • Beyond Aesthetics: Pomegranate's anti-inflammatory and antioxidant properties offer potential benefits beyond aesthetics. Its wound-healing capabilities and potential role in managing conditions like psoriasis warrant further investigation, highlighting its broader therapeutic potential. By staying aware of such research, dermatologists can contribute to holistic patient care.

Applications and Benefits:

  • Enhanced patient consultations: Armed with this knowledge, dermatologists can offer personalized advice on incorporating pomegranate into patients' skincare routines, considering their individual needs and potential interactions with existing medications.
  • Expanding treatment options: Pomegranate extracts offer promise as complementary or alternative therapies for certain skin conditions,potentially reducing reliance on conventional medications and their side effects.
  • Collaborative research opportunities: Dermatologists can collaborate with other fields to explore the deeper mechanisms of pomegranate's action and develop evidence-based recommendations for optimal skin health.

Conclusion: The results of the present study are very promising optimizing skin health in Dermatology Practice. Pomegranate polyphenols emerge as exciting allies in the dermatologist's toolkit. By understanding their multifaceted benefits, we can empower patients to achieve healthier, more resilient skin, both aesthetically and therapeutically. Let us continue to explore the power of nature and translate its wisdom into solutions for vibrant, healthy skin for all.


Vasiliki Lagouri BA MSc PhD received her three degrees from Aristotle University of Thessaloniki and National and Kapodistrian University of Athens, Greece: A BA from the Chemistry Department of Aristotle University of Thessaloniki, where she was awarded by the National Fellowships Foundation, the highest undergraduate honor, MSc in Medicinal Chemistry from Department of Pharmacy National and Kapodistrian University of Athens, and a PhD in Food Chemistry from Chemistry Department of Aristotle University of Thessaloniki. Post-graduate grants were awarded from the National Fellowships Foundation and Mpodosakis Foundation of Greece. She has more than 20 years research and academic experience at the Departments of Food Science and Technology, International Hellenic University of Thessaloniki and the Departments of Chemistry and Pharmacy, National and Kapodistrian University of Athens, National Hellenic Research Foundation of Athens and Perrotis college/American Farm School of Thessaloniki. She has 21 publications and 25 conference participations in the fields of food chemistry, medicinal chemistry, olive oil and natural products (number of citation 1006, h-index = 10 Google Scholar).