Title : Association between androgenetic alopecia and risk of cardiovascular events in young males: A systematic review and meta-analysis
Abstract:
Background: Androgenetic alopecia (AGA), often known as male-pattern baldness, is a common dermatological illness that mostly affects men and is defined by gradual hair thinning and loss. Multiple studies have investigated the potential relationship between AGA and cardiovascular events; however, the nature of this association is still debated. Furthermore, the link between AGA and CVDs appears to be stronger in young male population.
Objective: To systematically review the literature and conduct a meta-analysis to assess the relationship between AGA and Cardiovascular Risk Factors in Young Adult Males (<40 years at diagnosis).
Methods: We searched multiple electronic databases for studies evaluating the effects of AGA Cardiovascular risk factors in adults. Studies were included if they met predefined inclusion criteria. Data extraction and quality assessment were performed independently by two reviewers. Random-effects meta-analysis was conducted to estimate pooled effect sizes.
Results: The meta-analysis of three included studies, demonstrated a promising association between androgenetic alopecia (AGA) and cardiovascular risk, marked by elevated systolic blood pressure (SBP). The analysis indicated a noteworthy mean difference in SBP (?????= 9.6339), 95% CI: 0.8464 to 18.4215), affirming the significance of AGA as a potential indicator of cardiovascular risk. Despite the inherent variability of the data (I² = 91.7963%) due to fewer number of studies included, the robustness of the findings is underscored by a comprehensive prediction interval. One study was identified as a potential outlier, but no studies were found to be excessively influential.
Conclusion: Current research suggests a potential link between androgenetic alopecia (AGA) and cardiovascular events, yet is limited by the confounding presence of metabolic syndrome. Given its rising prevalence, further large-scale studies are essential to ascertain AGA's role as an independent risk factor. Early detection and management of AGA could be crucial in mitigating future cardiovascular risks, emphasizing the need for regular screening and awareness of associated health implications.
