Title : Lymphoproliferative diseases in the practice of a dermatologist
Abstract:
Lymphoproliferative diseases with skin lesions at the beginning of development can mimic various inflammatory dermatoses.
The report will examine cases of lymphomas (T-cell, including angioimmunoblastic, B-cell, NK-cell, histiocytosis from Langerhans cells) that have been observed in patients who have consulted a dermatologist.
The options of differential diagnosis, including those with metastases of malignant tumors in the skin, are considered. The report will provide clinical examples of patients from infancy to old age.
Thus, a patient from 6 months to 2.5 years old was diagnosed with viral warts, chickenpox, molluscum contagiosum, and pyoderma of the scalp. During a skin biopsy of the lesion at the age of 2.5 years, the first histological diagnosis was "nevus", and only an immunohistochemical study due to inconsistencies in clinical and laboratory data allowed the diagnosis of histiocytosis from Langerhans cells. Another example is an 87-year-old man who was diagnosed with folliculitis of the scalp, and a biopsy revealed leg-type lymphoma, despite its location not on the lower legs. A 57-year-old patient with vulgar pemphigus receiving prednisone reported varicose veins on the lateral surface of the foot, the nodular nature of the skin changes was an indication for a biopsy, which confirmed endemic Kaposi's sarcoma.
The issues of the difficulties of histological confirmation, the choice of therapy tactics and patient routing will also be discussed.
