Title : Pro-inflammatory cytokines TNF-alpha, IL-6 and IL-8 at patients with idiopathic type of Kaposi's sarcoma
Immune system controls tumor growth due to cellular mechanisms and cytokines - mediators of intercellular interactions. Activity of some cytokines is used by the body in the implementation of antitumor surveillance. The most important cytokines are T cell growth factors, such as IL-2, IL-4, immunoregulatory cytokines associated with the type of T helper response (IFN-γ, IL-4, IL -12, TNF, IL-10), Polarization of T-helpers is associated with the activation pro-inflammatory cytokines. The aim of the study was to determine the state of proinflammatory cytokines TNF-alpha, IL-6 and IL-8 in patients with idiopathic type of Kaposi's sarcoma (ICS). There were 72 patients with ICS under observation. The level of cytokines was determined in serum using ELISA. The level of TNF-alpha in the sera of patients with ICS was significantly different from that of healthy individuals (110,6+17,5 pg/ml vs 25,5±2,1 pg/ml). Fluctuations in the concentration of TNF in the blood serum with ICS within the average error was 80-130 pg/ml. One of the main functions of IL-6 is the regulation of antibody-producing cells from B-lymphocytes and the production of immunoglobulins, plays a central role in nonspecific antiviral immunity, along with TNF-α. High reliable IL-6 concentrations of 28,9±3,5 pg/ml correlate with a high B-lymphocyte content and IgG concentration. There was also a hyperproduction of IL-8 33,4±4,1 pg/ml versus 6,8±1,6 pg/ml. The change in the concentration of cytokines in the blood serum make it possible to prove the role of pro-inflammatory cytokines in the pathogenesis of ICS. Tumor cells can themselves produce IL-6 and TNF-alpha, which are growth factors that ensure the immunoreficiency of the tumor tissue and the inhibition of the T-cell link of immunity. Obviously, these cytokines are diagnostic criteria for the malignancy of the process.
Dr. Khalidova Khalida Rashidovna has been working at the Republican Specialized Scientific and Practical Medical Center for Dermatovenereology and Cosmetology of the Ministry of Health of the Republic of Uzbekistan for 30 years. She is the head of the PCR laboratory, she has been studing and treating AIDS-associated diseases (Kaposi's sarcoma) and STD. She received PhD degree in 2000 at the same institution. She has published more than 200 research articles in different scientific journals.