Title : Pro-inflammatory cytokines TNF-alpha, IL-6 and IL-8 at patients with idiopathic type of Kaposi's sarcoma
Immune system controls tumor growth due to cellular mechanisms and cytokines - mediators of intercellular interactions. Activity of some cytokines is used by the body in the implementation of antitumor surveillance. The most important cytokines are T cell growth factors, such as IL-2, IL-4, immunoregulatory cytokines associated with the type of T helper response (IFN-γ, IL-4, IL -12, TNF, IL-10), Polarization of T-helpers is associated with the activation pro-inflammatory cytokines. The aim of the study was to determine the state of proinflammatory cytokines TNF-alpha, IL-6 and IL-8 in patients with idiopathic type of Kaposi's sarcoma (ICS). There were 72 patients with ICS under observation. The level of cytokines was determined in serum using ELISA. The level of TNF-alpha in the sera of patients with ICS was significantly different from that of healthy individuals (110,6+17,5 pg/ml vs 25,5±2,1 pg/ml). Fluctuations in the concentration of TNF in the blood serum with ICS within the average error was 80-130 pg/ml. One of the main functions of IL-6 is the regulation of antibody-producing cells from B-lymphocytes and the production of immunoglobulins, plays a central role in nonspecific antiviral immunity, along with TNF-α. High reliable IL-6 concentrations of 28,9±3,5 pg/ml correlate with a high B-lymphocyte content and IgG concentration. There was also a hyperproduction of IL-8 33,4±4,1 pg/ml versus 6,8±1,6 pg/ml. The change in the concentration of cytokines in the blood serum make it possible to prove the role of pro-inflammatory cytokines in the pathogenesis of ICS. Tumor cells can themselves produce IL-6 and TNF-alpha, which are growth factors that ensure the immunoreficiency of the tumor tissue and the inhibition of the T-cell link of immunity. Obviously, these cytokines are diagnostic criteria for the malignancy of the process.