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Title: Radiation-induced skin toxicity in breast cancer patients: A systematic review of randomized trials

Saleh Aljabri

Sunnybrook Health Sciences Centre, Canada

Biography

Saleh Aljabri is originally from Saudi Arabia, but grew up in Scotland before returning to complete his medical degree in 2011 from King Saud University in Riyadh. As a medical student, Dr. Aljabri cofounded the Save A Life campaign for organ donation; he also serves as a aboard member of the New East Philantropic Foundation. During his internship at Khalid university hospital, his focus was on Dermatology. Following that, he worked at a resident in the dermatology department at Security Forces Hospital. Dr. Aljabri is interested in autoimmune skin diseases and has attended many clinics in the National Center of Vitiligo. In October 2017, Dr. Aljabri completed the Saudi Dermatology residency program.

Abstract

Despite clear benefits of radiotherapy (RT) for breast cancer, there are numerous side effects. One of those side effects is Radiation dermatitis (RD) which has a significant impact on quality of life and can result in treatment interruptions or cessation. RD usually appears within 1 to 4 weeks of starting radiation, and remains or continues to increase for the duration of RT. The purpose of this study was to prospectively follow breast radiation dermatitis and determine trends including peak toxicity.

 All patients who received adjuvant breast or chest wall RT at the Sunnybrook Odette Cancer Centre between December 2013 and November 2015 were eligible for the study. Upon initiation of RT treatment, patients were seen weekly by the healthcare team to assess their skin reaction until the last week of RT. Records of RD obtained after completion of RT were collected via telephone contact with the patient to assess patient reported symptoms or in a follow up visit with the treating radiation oncologist. Weekly progression of radiation dermatitis was assessed using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.03. A variety of treatment positions were used as per the treating physician’s preference. Patients were stratified for analysis of RD based on RT technique and dosage. Reports of RD were stratified by week following RT for the purposes of this study.