Title: Role of the transcription factor p63 in regenerative capacity of skin stem cells

Makoto Senoo

Boston University School of Dental Medicine, USA


Dr. Makoto Senoo is Associate Professor in the Department of Molecular and Cell Biology at the Boston University School of Dental Medicine. Dr. Senoo is a pioneer in the p63 field since its discovery in 1997. His lab focuses on intrinsic and extrinsic regulation of homeostasis and diseases of epithelia with a long-term goal of developing stem cell-based therapeutic options.


Homeostasis and regeneration of the skin are maintained by self-renewal, proliferation, and differentiation of tissue-specific stem cells. We have shown previously that the transcription factor p63 plays an essential intrinsic role in regulating self-renewal of skin stem cells. In this keynote speech, I will present three short stories developing in our laboratory surrounding the control of homeostasis and regeneration of the skin.

(1) Control of the cell cycle progression in skin stem cells by p63.

(2) Regulation of dermal adipocytes by skin stem cells via paracrine signaling.

(3) Rapid enrichment and expansion of skin stem cells for regenerative medicine.