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Title: Nanostructured Lipid Carriers gel for dermal delivery of pranoprofen

Maria Rincon

University of Barcelona, Spain

Biography

University Education:

University Degree in Pharmacy – University of Salamanca. Spain. 2002 – 2007

Master in “Management and Production in Pharmaceutic Industry” – University of Salamanca. Spain. 2007-2008.

Doctorate programme in Neurosciences “Morphologic and functional organization of Nervous System” – University of Salamanca. Spain. 2007-2009.

Doctorate programme in Development and control of drug delivery systems “Lipid nanostructured systems of pranoprofen for dermal application” – University of Barcelona.

Specialist Education:

Specialist in Industrial Pharmacy through national public examination (FIR) – University of Barcelona. 2015 – 2017

Abstract

Pranoprofen (PF), 2-(5H-[1] benzopyrano- [2, 3-b]-pyridin-7-yl) propionic acid, is a nonsteroidal anti-inflammatory drug used in ophthalmology. Recently, some articles have reported the effect of this drug for the treatment of skin diseases. Nanostructured Lipid Carriers (NLC) are one of the colloidal systems that have been most widely studied over the past few decades with the aim of improving the penetration and delivery of drugs in the skin.

      Propose: Development and evaluation of carbomer gel bearing pranoprofen loaded nanostructured lipid carries as a means of exploring novel formulations to               improve the biopharmaceutical profile of this drug for skin disorders.

Methods and Results: The PF-NLC were optimized by a factorial design and characterized physiochemically, subsequently these systems were incorporated in a matrix of carbomer gels and studies such as release, ex vivo permeation using human skin, in vivo biomechanical properties and irritation test were carried out. Moreover, stability studies were determined using a Turbiscan Lab®.

The PF-NLC-gels exhibited physicochemical characteristics and morphological properties suitable for dermal application. Also, the release profile showed a hyperbola Kinetic model. No signs of skin irritancy were detected. The measure of the transepidermal water loss (TEWL), and stratum corneum hydration (SCH) showed an occlusive and a moisturizing effect. For the stability, formulations were stable for a period of 6 months. Taking into account these results, the PF loaded in nanostructured systems could be a new alternative for the treatment of skin disorders.

Audience take away:

  • The PF-NLC and PF-NLC-gels could be effectives systems for the delivery and controlled release of the drug in the skin, also improving the biopharmaceutical profile of the drug, facilitating the contact of the PF on the skin and improving its dermal retention. Then reducing the dermal oedema and enhanced the anti-inflammatory effect to this drug, also this is a new route of application for this drug, could be effective to treat different inflammatory disorders in the skin as rosacea  or atopic dermatitis.