Title: Inositolo and Acne

Michele Pezza

Casa di Cura Villa Maria, Italy


To be updated soon..


The aim of the study was to identify a therapy able to block the DHEAS in women who do not have contraindications or adverse events to estrogen-progestin therapy (e.g. increased risk of thrombosis and side effects Associated with the use of progestinic estrogen). The aim of our study was to determine the effects of inositol in the treatment of patients suffering from PCOS and acne. It is a spontaneous prospective pilot study performed in two centers in Italy that have surgeries dedicated to dermatological diseases. According to a randomization table, the patients were divided into two groups.

Group A

50 patients prescribed:

2 grams of inositol, 2 times a day, orally

Group B

50 patients prescribed:

2 grams of placebo 2 times a day, orally, for six months

The randomization occurred through the assignment entrusted to a specialized agency that by telephone and independently of the DERMATOLOGIC study centers assigned the patients to one of the two groups. In group A, the blood levels of dheas have been reduced. In group B, the blood levels of dheas were almost unchanged. In addition, an improvement of the cutaneous clinical picture was also found in patients with improvement of GEA (Global Evaluation acne) and Cadi (Cardiff acne Disability Index). In conclusion, these observations suggest that inositol may be useful as adjunctive therapy in the treatment of female patients with acne, especially in the case of women who cannot receive combined estrogen-progestin therapy.