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Melanoma is the deadliest and most aggressive type of skin cancer. Melanoma develops when melanocytes, the pigment-producing cells present in the skin, eye, inner ear, and leptomeninges, acquire genetic mutations. UV radiation is the primary cause of melanoma in people who have low amounts of the skin pigment melanin. Any skin lesion that has indications of being potentially malignant is biopsied and analyzed for diagnosis. Melanoma, a malignant cancer emerging from melanocytes, is a rare disease in the United States, affecting only 22.1 persons per 100,000. It is, nevertheless, a notably deadly disease, accounting for 75% of skin cancer deaths despite only accounting for 4% of skin cancer cases. The mnemonic "ABCDEF" summarizes the early signs of melanoma: Asymmetry, Borders (irregular with edges and corners), Color (variegated), Diameter (greater than 6 mm (0.24 in), Evolving over time

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