Skin is the most exposed organ to the external environment, and it serves as the first line of defense against chemical and microbial dangers. It has a microbiological habitat that is unique to each individual and varies greatly across the body surface. In both acute and long-term care, maintaining and improving skin health and integrity are important goals. Skin integrity is regarded as a quality indicator, and it is widely accepted that maintaining skin integrity is important. Skin personal care products are universally used, but their effects on the skin's molecular and microbiological diversity are unknown. Aspects of aesthetics such as skin health are crucial. To achieve this goal, dermatologists and scientists are working to develop new methods and materials.