Title : Dermatologic procedures for treating lichen planus pigmentosus: A review
Abstract:
Lichen pigmentosus planus (LPP) is a rare pigmentary disorder primarily affecting patients with skin of color. Various dermatologic procedures demonstrated efficacy in treating other pigmentary disorders and may provide valuable options for treating refractory LPP. However, comprehensive evaluations for procedural interventions for LPP are limited. In this review we assess current procedural options for LPP treatment, focusing on their efficacy, safety and practical considerations. A comprehensive literature search using PubMed and Embase identified English studies published through December 2024 that examined dermatologic procedures for the treatment of LPP. Keywords included “lichen planus pigmentosus,” “laser,” “chemical peel,” “glycolic acid,” “salicylic acid,” “TCA,” “jessner,” “VI,” “cosmetic procedure,” “procedure”, and related terms. Articles without original data, sufficient results, or human subjects were excluded. Data on study design, participant characteristics, procedural details, and clinical outcomes were extracted and reported in this descriptive review. 17 studies were reviewed which highlighted procedural approaches to managing LPP including chemical peels (e.g. phenol and glycolic acid), laser therapy (e.g. Q-switched Nd:YAG, CO2 fractional, Picosecond Nd-YAG, erbium-doped fiber,) platelet-rich plasma therapy, and narrow-band ultraviolet B phototherapy. Evidence was limited by small sample sizes, lack of randomized control trials and reliance on case reports and series. Most studies included fewer than 20 participants, limiting the generalizability of findings. Procedural interventions offer a valuable addition to the treatment for LPP, especially for those unresponsive to standard treatments. Further research with larger cohorts and comparative trials are needed to further elucidate current findings.
