Drug-induced skin reactions are adverse effects resulting from medications, manifesting as various dermatological conditions. Common reactions include rashes, urticaria (hives), and photosensitivity, which can occur shortly after starting a new medication or even after prolonged use. The severity of these reactions can range from mild irritation to life-threatening conditions like Stevens-Johnson syndrome. Identification of the offending drug is crucial for effective management, often involving withdrawal of the medication and symptomatic treatment. Dermatologists play a key role in diagnosing these reactions, using clinical history and sometimes patch testing. Understanding drug-induced skin reactions is essential for safe prescribing practices and patient education in both dermatology and cosmetology, as some treatments may exacerbate existing sensitivities.