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Genetic Makeup

Genetics play a major role in the etiology of human dermatologic conditions. It is now well accepted that inherited genetic variations often involve the alteration of disease states, sun sensitivity, skin color, and aging. The field of dermatology is rapidly advancing due to increased awareness and research into the genetic basis of skin disease. The expression of a phenotype, such as a skin disease, can be based on the complex interactions of multiple genes. This is referred to as polygenic inheritance. So far, many genetic mutations have been identified that cause specific dermatologic disorders. For example, a mutation in the connexin 26 gene results in a genetic condition called congenital deafness-onychodystrophy syndrome, which is characterized by hearing loss, nail deformities, and skin fragility. Genetic testing can help to identify these mutations in individuals with a suspected dermatologic condition. The study of epigenetics is also important in dermatology. It entails the modifications to gene expression made without changes to the DNA sequence. This can involve chemical markers attached to the DNA, such as methylation or acetylation, or other processes like chromatin remodeling or post-transcriptional regulation. Epigenetic modifications can influence gene expression, and consequently influence cellular phenotype, including skin structure and function. Finally, genome-wide analyses have become increasingly important in understanding the genetic basis of skin disease. By comparing the genome sequences of individuals with and without a particular dermatologic condition, researchers can identify genetic variants that may be associated with that disorder. Such studies can then further inform the development of new diagnostic tests, treatments, and preventive measures. Overall, recent advances have vastly improved our understanding of the genetic basis of dermatologic conditions. This makes genetic testing a useful tool for diagnosing, managing, and preventing these diseases.

Committee Members
Speaker at Dermatology and Cosmetology 2025 - Sergei A Grando

Sergei A Grando

University of California Irvine, United States
Speaker at Dermatology and Cosmetology 2025 - Gustavo Hector Leibaschoff

Gustavo Hector Leibaschoff

World Society of Cosmetic Gynecology, United States
Speaker at Dermatology and Cosmetology 2025 - Nalini Kaul

Nalini Kaul

Princeton Consumer Research, Canada
Speaker at Dermatology and Cosmetology 2025 - Dechelette Corinne

Dechelette Corinne

La Peau Autrement, France
IDC 2025 Speakers
Speaker at Dermatology and Cosmetology 2025 - Rachita Dhurat

Rachita Dhurat

LTMMC & LTMG Hospital, India
Speaker at Dermatology and Cosmetology 2025 - Frederick H Silver

Frederick H Silver

Robert Wood Johnson Medical School, Rutgers University, United States
Speaker at Dermatology and Cosmetology 2025 - Daan Thorn Leeson

Daan Thorn Leeson

Rodan + Fields, United States
Speaker at Dermatology and Cosmetology 2025 - Brannon Claytor

Brannon Claytor

Claytor Noone Plastic Surgery, United States
Speaker at Dermatology and Cosmetology 2025 - Katie L Frederickson

Katie L Frederickson

Meharry Medical College, United States
Speaker at Dermatology and Cosmetology 2025 - Xiaozhun Hang

Xiaozhun Hang

Queensland Institute of Medical Research Berghofer, Australia

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