Genetics play a major role in the etiology of human dermatologic conditions. It is now well accepted that inherited genetic variations often involve the alteration of disease states, sun sensitivity, skin color, and aging. The field of dermatology is rapidly advancing due to increased awareness and research into the genetic basis of skin disease. The expression of a phenotype, such as a skin disease, can be based on the complex interactions of multiple genes. This is referred to as polygenic inheritance. So far, many genetic mutations have been identified that cause specific dermatologic disorders. For example, a mutation in the connexin 26 gene results in a genetic condition called congenital deafness-onychodystrophy syndrome, which is characterized by hearing loss, nail deformities, and skin fragility. Genetic testing can help to identify these mutations in individuals with a suspected dermatologic condition. The study of epigenetics is also important in dermatology. It entails the modifications to gene expression made without changes to the DNA sequence. This can involve chemical markers attached to the DNA, such as methylation or acetylation, or other processes like chromatin remodeling or post-transcriptional regulation. Epigenetic modifications can influence gene expression, and consequently influence cellular phenotype, including skin structure and function. Finally, genome-wide analyses have become increasingly important in understanding the genetic basis of skin disease. By comparing the genome sequences of individuals with and without a particular dermatologic condition, researchers can identify genetic variants that may be associated with that disorder. Such studies can then further inform the development of new diagnostic tests, treatments, and preventive measures. Overall, recent advances have vastly improved our understanding of the genetic basis of dermatologic conditions. This makes genetic testing a useful tool for diagnosing, managing, and preventing these diseases.
Title : Integrating personalized and precision medicine into dermatology clinical practice securing ITS potential to get skin diseases cured and to revolutionize dermatology
Sergey Suchkov, National Center for Human Photosynthesis, Mexico
Title : Global perspectives on skin health: Diversity in dermatology and cosmetology
Dave Ray, Dave Ray Enterprises., United States
Title : How to correct cosmetic procedures gone wrong
Bharti Magoo, Golden Touch Clinic, India
Title : Epitomic analysis revealed pemphigus autoantibodies against the ligand-binding pocket of M3 muscarinic acetylcholine receptor
Sergei A Grando, University of California Irvine, United States
Title : Perspectives on healthy skin aging and pre-aging concepts
Georgios Stamatas, SGS France, France
Title : Efficacy and safety of rituximab versus pulse therapy in immunobullous disorders: A retrospective study
Ravi M Rathod, KMCRI, India
Title : Dermatology and cosmetology through art and history of art
Dechelette Corinne, La Peau Autrement, France
Title : Acne vulgaris and the most popular and new cosmetological treatments
Karolina Chilicka Hebel, University of Opole, Poland
Title : Stem cells in dermatology and cosmetology
Makoto Senoo, Cell Exosome Therapeutics Inc, Japan
Title : Standards, education and application of special cosmetic treatments in cosmetology practice
Elizabeta Popova Ramova, University MIT Skopje, Macedonia, The Former Yugoslav Republic of